Duloxetine Dosage: What You Need to Know About Strengths, Timing, and Safety

When you're prescribed duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat depression, anxiety, and chronic pain. Also known as Cymbalta, it works by balancing brain chemicals that affect mood and pain signals. But knowing the right duloxetine dosage isn't just about following a number—it’s about matching the dose to your condition, your body, and how you respond over time.

Duloxetine comes in capsules with strengths of 20 mg, 30 mg, and 60 mg. For depression, most people start at 30 mg once daily, then move up to 60 mg after a week if needed. For generalized anxiety disorder, the same starting dose applies, but some patients stay at 30 mg if it works well. If you're using it for diabetic nerve pain or fibromyalgia, 60 mg once a day is the typical target. Never crush or open the capsule—swallow it whole with water. Taking it at the same time each day helps keep levels steady. Many people take it in the morning to avoid sleep issues, but if it makes you drowsy, switching to evening might help.

What makes dosage tricky is how your body handles it. If you have liver problems, your doctor might lower the dose. Older adults often start at 30 mg because they’re more sensitive to side effects like dizziness or dry mouth. And if you’ve been on it for months, stopping suddenly can cause brain zaps, nausea, or irritability. That’s why tapering down slowly under a doctor’s care matters. Duloxetine doesn’t work the same for everyone—some feel better in days, others need weeks. It’s not a quick fix, but when the dose is right, it can change how you move through daily life.

Side effects like nausea, fatigue, or constipation are common at first but often fade. If they don’t, or if you notice mood changes, increased anxiety, or unusual bleeding, talk to your provider. It also interacts with other meds—especially SSRIs, NSAIDs, or blood thinners—so always list everything you’re taking. This page collects real-world insights from people managing depression, anxiety, and nerve pain with duloxetine. You’ll find guides on adjusting doses, handling side effects, and what to expect when you start or stop. No fluff. Just clear, practical info to help you take control.