Corticosteroid Ulcer Prevention: How to Protect Your Stomach While Using Steroids

When you take corticosteroid, a class of powerful anti-inflammatory drugs used for conditions like arthritis, asthma, and autoimmune diseases. Also known as steroids, they can reduce swelling and calm overactive immune responses—but they also raise your risk of stomach ulcers. This isn’t just a side effect you might read about in a pamphlet. Studies show that people on long-term corticosteroids like prednisone or methylprednisolone are up to four times more likely to develop ulcers, especially if they’re over 60, smoke, or take NSAIDs like ibuprofen at the same time.

So how do you stop this from happening? It’s not just about popping an antacid. True corticosteroid ulcer prevention, a strategy focused on reducing gastrointestinal damage caused by steroid use means combining medication, lifestyle changes, and smart monitoring. Proton pump inhibitors (PPIs) like omeprazole are the most effective shield—they block acid production at the source. H2 blockers like famotidine help too, but they’re not as strong. And no, milk or antacids won’t cut it for long-term protection. You also need to avoid alcohol, quit smoking, and skip NSAIDs unless absolutely necessary. Even then, talk to your doctor about alternatives like acetaminophen for pain. If you’re on steroids for more than a few weeks, your doctor should be checking in on your stomach health—not just your joints or lungs.

It’s not just about the drugs you take. Your habits matter just as much. Eating smaller meals, avoiding late-night snacks, and not lying down right after eating can cut your risk. Stress doesn’t cause ulcers, but it makes them worse—and steroids already strain your body. Simple breathing exercises, regular walks, or even just getting enough sleep can help your gut recover. And if you’ve ever had a stomach ulcer before? That’s a red flag. You’ll likely need ongoing protection, not just a one-time fix.

Below, you’ll find real comparisons and practical advice from people who’ve been there. We’ve pulled together posts that break down how different steroids like Medrol and prednisone affect your gut, what works to protect you, and which remedies actually deliver results—without hype or guesswork.